Monday, November 10, 2008

NC Medical Board Statement on Drug Overdose Prevention

The North Carolina Medical Board has published the following Position Statement on Drug Overdose Prevention.
Drug Overdose Prevention

The Board is concerned about the three-fold rise in overdose deaths over the past decade in the State of North Carolina as a result of both prescription and non-prescription drugs. The Board has reviewed, and is encouraged by, the efforts of Project Lazarus, a pilot program in Wilkes County that is attempting to reduce the number of drug overdoses by making the drug naloxone* and an educational program on its use available to those persons at risk of suffering a drug overdose.
The prevention of drug overdoses is consistent with the Board’s statutory mission to protect the people of North Carolina. The Board therefore encourages its licensees to cooperate with programs like Project Lazarus in their efforts to make naloxone available to persons at risk of suffering opioid drug overdose. * Naloxone is the antidote used in emergency medical settings to reverse respiratory depression due to opioid toxicity.

Tuesday, September 9, 2008

Why We Shouldn't Blame Benzos

Sometimes I hear from well-meaning medical practitioners that methadone is unfairly maligned as it is blamed for so many deaths. Benzodiazepines, these doctors argue, are to blame for so many methadone poly-drug deaths. Benzodiazepines are the real killers. I don't buy it. While admittedly the dangers of combining benzodiazepines with methadone are well-known in the medical community, many people dependent on benzodiazepines continue to use them for years and years, without dying. In addition, benzodiazepines are highly addictive, and withdrawal can lead to fatal seizures. The New York Times recently reported:

"A majority of victims also used large quantities of alcohol or benzodiazepine sedatives but few would have died without an opioid as the primary culprit. 'You can take a lot of benzodiazepines without dying,' said Dr. Charles E. Inturrisi of Weill Cornell Medical Center, who said they strengthen the depressive effect of methadone."

What I am concerned about more than all the people using benzodiazepines, is all the doctors prescribing methadone to the people using benzodiazepines. A patient with a long-standing history of benzodiazepine use should not be started on methadone until the physician confirms the patient is benzodiazepine-free.

Why People Die From Methadone

There has been a debate for some time about why people are dying from methadone toxicity. I don't mean why methadone the drug causes deaths-- that is something that is well-understood in the medical/scientific community, given the highly variable half-life among individuals and the risks to those who are opiate naive. What I mean is that the medical community wants to blame deaths on the methadone clinics andn the methadone clinics want to blame the physicians, and when push comes to shove, they all would rather blame it on diversion. Diversion of methadone from those legally prescribed it is a problem, and street use of methadone is apparently responsible for thousands of deaths. That should make sense to us. But remember that if diversion is causing deaths, then the physicians prescribing it to patients who then lose it, sell it or have it stolen bear a large part of the responsibility for the methadone on the street. But as much as the educated and employed want to blame the "addicts" for this epidemic, many deaths are attributable not to street use, but to use as prescribed by a physician. Eric Eckholm with the New York Times recently reported: "Misuse by abusers was first seen as the problem, but now, said Dr. H. Westley Clark, director of the Center for Substance Abuse Treatment of SAMHSA, 'We know that a significant share of the methadone deaths involve doctors making well-intended prescriptions.'" That is what is so tragic about methadone deaths in the U.S. The following study from the Jouornal of Forensic Sciences found over 48% of methadone deaths werew attributable to well-intended presciptions by doctors.

Methadone toxicity fatalities: a review of medical examiner cases in a large metropolitan area.
J Forensic Sci. 2007 Nov;52(6):1389-95.
Shields LB, Hunsaker Iii JC, Corey TS, Ward MK, Stewart D.
Office of the Chief Medical Examiner, Urban Government Center, Louisville, KY 40204, USA.
Over the past several years, Medical Examiners in Kentucky and around the nation have observed a dramatic rise in drug intoxication deaths involving the prescription medication methadone. This documented rise in methadone-related deaths requires a better understanding of methadone's pathophysiology and the ways it contributes to significantly increase morbidity and mortality. This study reviews 176 fatalities ascribed to methadone toxicity by the Office of the Chief Medical Examiner in Kentucky between 2000 and 2004. Postmortem toxicological analysis recorded a more than 10-fold increase in methadone toxicity fatalities, rising from 6 cases in 2000 to 68 cases in 2003. Of the 176 methadone-related fatalities, methadone was the only drug detected in postmortem blood and urine toxicological analyses in 11 (6.25%) cases. The mean methadone blood concentration of all 176 cases was 0.535 mg / L (0.02-4.0). The following psychoactive medications were detected: antidepressants (39.8%), benzodiazepines (32.4%), and other opioids in addition to methadone (27.8%). Cannabinoids were detected in 44 (28.4%) cases and cocaine or metabolite in 34 (21.9%) cases. Of the 95 cases with a known history of methadone use, 46 (48.4%) involved prescription by private physician. The interpretation of blood methadone concentrations alone or combined with other psychoactive drugs requires consideration of the subject's potential chronic use of and tolerance to the drug. A thorough investigation into the practices of procurement and use/abuse of methadone is essential to arrive at the proper designation of the cause of death.

Wednesday, August 13, 2008

Project Lazarus

Project Lazarus is a pilot program in Wilkes County, NC, to provide intranasal naloxone to patients at risk of opiate overdose. Naloxone is administered to reverse the CNS depressant effects of opiates. The pilot program will provide free naloxone kits to health care providers, who can then provide them to high risk patients and families, to use in the event of opiate poisoning. To read more about the project and the data supporting it, click on this link.

http://www.ncmedboard.org/Clients/NCBOM/Public/PublicMedia/lazarus.pdf

Of the people I know who lost a family member to opiate toxicity, including oxycontin, methadone and fentanyl, having a naloxone kit would have been useless, because they did not appreciate at the time that the family member was dying. Respiratory depression occurs over time. Families report that the person was sleepy, breathing heavily and snoring for several hours before he was found dead. The families thought nothing was wrong, and they did not intervene. For each family I know who lost a son or father to methadone overdose, they had plenty of time to call EMS, had they only known they were witnessing respiratory depression. But they didn't know, so they didn't call. Education and informed consent, it seems to me, will go a long way toward preventing unintentional deaths from methadone and other opiates. Naloxone is not a bad idea. But the education that is sure to come to the patients who are given the naloxone is what we really need.

Doctors Settlements and Verdicts To Be Published in NC

The N.C. Medical Board has passed a new rule requiring the posting of certain payments made by physicians in NC to patients as a result of a claim of negligence. The measure was hotly debated, and the question has been posed whether giving the public access to this information will serve the public. Information for its own sake can be debated. But from a purely practical standpoint, the question is whether the posting will change anyone's behavior. I suppose that depends on whether patients use the medical board site to gather information about prospective physicians before scheduling an appointment. The effect of the new rule thus far has been to prevent settlements of cases currently in litigation. Seems that some doctors who were perviously open to settling a claim are now choosing to take a chance that a jury will not find them liable for a patient's injury. Does that ultimately serve the public? We will watch and see.

Thursday, May 8, 2008

Florida Death from Prescribed Methadone

Florida has passed legislation known as "tort reform" which places limits on what a person can recover in a medical malpractice case. For example, the statute sets out who can claim a loss for the death of a person, and what kinds of losses can be claimed. Funeral expenses are recoverable, as is the wage loss to the heirs of the deceased. But what if the person who died had no children and no spouse? What are the losses? His lost wages are not recoverable, as no one was depending on his income. His funeral expenses are recoverable. His parents can claim a loss for his society and companionship. But the statute caps the amount of money that can be awarded for this loss. A mother called me yesterday to tell me that she has contacted law firms who have refused her case because her son who was given a drug overdose in a hospital had no heirs or spouse and the case "just wasn't worth it." If there is no consequence to medical providers who cause the death of a patient, will the medical providers change their behavior? How can the loss of a human life be "just not worth it?"

Oxycodone Dosing Error

I got a call a couple of weeks ago from a grieving father. He found his 27 year old son dead in his bed one morning in February. His son had earlier that day been to a new doctor for his chronic back pain, and the doctor had prescribed 120mg of oxycontin /oxycodone without any information from the young man that he could tolerate this high dose. The labelling for oxycontin describes a starting dose of 10 mg. The cause of death has been ruled oxycodone toxicity.

The Label on the Pill Bottle

Terry Paul Smith, a 46-year-old roofer, suffered from a disorder of the peripheral nerves (neuropathy) in his back and legs, which kept him in chronic pain. He took Oxycontin and Neurontin, but he disliked the way it made him feel, e.g., making him sometimes "drop out" in the middle of a conversation. After he complained about the pain medications' side effects, his doctor changed the prescription to methadone. The doctor wrote a prescription for Terry to take four 10-milligram pills, twice a day. Terry filled the prescription at a local Walgreen's pharmacy in Jacksonville, Florida. The label on the pill bottle directed Terry to take four tablets "as needed for chronic pain," and did not mention any limits on the frequency. Terry took the pills for the first time on July 23-24, 2001. Within 36 hours, Terry was dead. The autopsy found toxic levels of methadone in his blood. The pharmacist's error to "take as needed" rather than take "twice a day" increased the risk of Terry's death. Now Terry's widow, Pearl Smith, is pursuing a lawsuit against Walgreen's. A company spokesman says Walgreen's has spent $1 billion over the last decade on pharmacy safety systems, safety training and technology. Walgreen's filled more than half a billion prescriptions in the last fiscal year.

This overdose death illustrates the importance to discuss the doctor's prescribing orders with her and check her prescription carefully against the label on the bottle, especially for a new medicine. Read an informed consent story, or read more from the source article by Kevin McCoy in the USA Today of Nov. 2.

Tuesday, March 4, 2008

Methadone Dosing

I am not a doctor. I do not treat patients with methadone. I do not prescribe methadone. But in the methadone death cases I have seen and in my discussions with physicians, pharmacologists and toxicologists, the issue of safe dosing has been front and center. The problem with dosing methadone, is that one size does not fit all. Some people can tolerate higher initial doses than others. While a low dose of methadone (2.5 mg three times of day) is thought to be well-tolerated even in opiate naive individuals, a person beginning even this protocol of methadone therapy should be carefully monitored for side effects that could indicate respiratory depression. One pain doctor I know starts patients at 2.5 mg, 3-4 times a day, unless he has solid confirmation from previous pharmacy and medical records that a person has been continuously using opiates at a determined level. This same physician increases the dose only every 7 days, and only by 2.5 mg. Sure, other pain doctors may criticize him for a dosing schedule that may not provide complete analgesia to pain patients during the initial phase of methadone treatment, but this pain doctor would rather endure that criticism than lose a patient to overdose. For more information about safe dosing of methadone in pain settings, the FDA cites Goodman F., Jones W., Glassman P., Methadone Dosing Recommendations for Treatment of Chronic Pain, Pharmacy Benefits Management Strategic Healthcare Group, United States Department of Veterans Affairs, December 2001.

Methadone clinics are known to start their patients at higher initial doses because of their goal of addressing withdrawal symptoms and the belief that opiate-tolerant patients can safely receive higher doses. But methadone clinics must also use caution in determining the initial starting dose, and must match the dose to the level of withdrawal and the history of opiate use. Good physicians will tell you that a person in mild withdrawal from low level daily opiate use should be started at a lower dose of methadone than a patient in raging withdrawal from high level daily opiate use. SAMHSA has warned that the 40 mg a day federal limit for methadone clinic patients should not be a one-size-fits-all dose. If clinics dose all their patients at this initial dose, patients will die.

FDA Advisory: Respiratory Depression and Death

FDA Public Health Advisory: Methadone Use for Pain Control May Result in Death and Life-Threatening Changes in Breathing and Heart Beat

ADVISORY--FDA has received reports of death and life-threatening side effects in patients taking methadone. These deaths and life-threatening side effects have occurred in patients newly starting methadone for pain control and in patients who have switched to methadone after being treated for pain with other strong narcotic pain relievers. Methadone can cause slow or shallow breathing and dangerous changes in heart beat that may not be felt by the patient. Prescribing methadone is complex. Methadone should only be prescribed for patients with moderate to severe pain when their pain is not improved with other non-narcotic pain relievers. Pain relief from a dose of methadone lasts about 4 to 8 hours. However methadone stays in the body much longer—from 8 to 59 hours after it is taken. As a result, patients may feel the need for more pain relief before methadone is gone from the body. Methadone may build up in the body to a toxic level if it is taken too often, if the amount taken is too high, or if it is taken with certain other medicines or supplements.To prevent serious complications from methadone, health care professionals who prescribe methadone should read and carefully follow the methadone (Dolophine) prescribing information FDA is issuing this public health advisory to alert patients and their caregivers and health care professionals to the following important safety information:Patients should take methadone exactly as prescribed. Taking more methadone than prescribed can cause breathing to slow or stop and can cause death. A patient who does not experience good pain relief with the prescribed dose of methadone, should talk to his or her doctor. Patients taking methadone should not start or stop taking other medicines or dietary supplements without talking to their health care provider. Taking other medicines or dietary supplements may cause less pain relief. They may also cause a toxic buildup of methadone in the body leading to dangerous changes in breathing or heart beat that may cause death. Health care professionals and patients should be aware of the signs of methadone overdose. Signs of methadone overdose include trouble breathing or shallow breathing; extreme tiredness or sleepiness; blurred vision; inability to think, talk or walk normally; and feeling faint, dizzy or confused. If these signs occur, patients should get medical attention right away. FDA recently approved new prescribing information for methadone products approved for pain control. The information in the new prescribing information is based on a review of the scientific literature completed by FDA. A Medication Guide for patients is planned.

Zero Unintentional Deaths

The American Society of Anesthesiology has taken action regarding the increasing numbers of methadone deaths in the United States. And the ASA is a great organization to take such action: they count among their members people the common folk in America call "pain physicians." The ASA is engaged in an educational campaign entitled “Zero Unintentional Deaths” to reduce the number of accidental methadone deaths.
“Six Steps to Zero” highlights important rules for pain patients who are prescribed methadone:
1. Never take a prescription painkiller unless it is prescribed to you.
2. Do not take pain medicine with alcohol.
3. Do not take more doses than prescribed.
4. Use of other sedative or anti-anxiety medications can be dangerous.
5. Avoid using narcotic medications to facilitate sleep.
6. Lock up prescription painkillers.

I wish they had added this rule:

"If you get sleepy while taking methadone, call 911."

Many of my clients' families reported not understanding that drowsiness was a dangerous side effect of methadone, and remembering when their loved one retired to the bedroom to "sleep it off."
You can contact the ASA at Zero Unintentional Deaths c/o Life Source, 617 East 3900 South, Salt Lake City, UT 84106.

Phyllis Lile-King

Link For more information

Monday, March 3, 2008

Montana Methadone Deaths

I called up a coroner in Montana last week. I needed a document from him for a case I am investigating. When he learned I was a lawyer and looking into a methadone death, he struck up a conversation. He volunteered the following: Methadone is one of the most common drugs causing poisoning deaths in Montana. He has seen the numbers skyrocket in the last few years. I shared with him that my case involved a new prescription for methadone at 50 mg starting dose, which he remarked sounded "way too high." He shared with me he had one young man die of methadone and they learned that the prescription allowed him to take the drug as needed-- a recipe for disaster in a drug like methadone. He volunteered that, if I wanted to see patients dying from methadone, I needed to go to the VA Hospital. He said, "They are the worst." I said, "Have you called the medical board? Have you let them know that doctors need some education about this drug? "That is not my job," he said.

Phyllis Lile-King

Link to learn more

Methadone Leads Kentucky Deaths

FRANKFORT, Ky. (AP) - A state medical examiner's report says methadone is the prescription drug that was most frequently detected in the blood of fatal overdose victims. Methadone is commonly prescribed for treating patients suffering from chronic pain and medical professionals describe methadone as an effective tool for pain management. Overdose due to methadone is on the rise in Kentucky as reflected in the State Medical Examiners Annual Report. It lists 197 deaths related to the misuse of the prescription drug methadone last year. Methadone was detected in 41 percent of the 484 overdose death cases in Kentucky. A recent federal government study found that nationwide methadone-related deaths climbed to more than 38-hundred in 2004 from about 780 in 1999.

(Copyright 2007 by The Associated Press. All Rights Reserved.)

St. Petersburg Times 2/17/08

St. Petersburg Times


Deadly Combination: The drugs that are killing the most people right now didn't originate on the street, but with a prescription.

By CHRIS TISCH and ABBIE VANSICKLE,

Times staff writers

February 17, 2008


Prescription painkillers and anti-anxiety drugs are killing about 500 people a year in the Tampa Bay area, twice the number killed by illegal drugs such as cocaine and heroin.
Prescription drug overdoses killed 433 people in the bay area in 2006, up from 339 the year before. Though 2007 figures aren't complete, the area is on pace for about 550 deaths. That means prescription drug overdoses are likely to overtake car crashes as the leading cause of accidental death here.

"The numbers are pretty staggering," said Bill Pellan, director of investigations for the Pinellas-Pasco Medical Examiner's Office.

Statewide, prescription drug overdoses caused 1,720 deaths in 2006, up about 40 percent from just three years earlier. In 2007, the state was on a pace of about 2,000 deaths.
That many people would fill almost all the seats in Ruth Eckerd Hall. They would pack 15 Southwest Airlines jets. They would make up the entire student population of Armwood High School in Hillsborough County."There is clearly a lack of understanding across the state of the danger of these drugs," says Bill Janes, director of the Florida Office of Drug Control. "I would have to say it is a health crisis."

But the problem is more severe in the Tampa Bay area, where the number of deaths per capita is nearly 70 percent higher than the state.

Police report a surge in prescription drug-related crimes, including doctor shopping, prescription fraud and pharmacy robbery. Drug rehabilitation centers have treated a wave of prescription drug addicts in recent years. Methadone clinics now treat more people addicted to painkillers than heroin. "This has become an epidemic," says Circuit Judge Dee Anna Farnell, who runs the drug court in Pinellas County. "It was cocaine in the '70s, crack in the '80s. Now it's the abuse of pharmaceuticals."

Who's dying from prescription drug overdoses?

The St. Petersburg Times obtained autopsy records and investigators' reports for each of the 772 deaths caused by prescription drugs in 2005 and 2006 in Hillsborough, Pinellas, Pasco and Hernando counties. The newspaper built a database and discarded 127 cases in which the manner was suicide or undetermined.
The Times analyzed the remaining 645 accidental deaths for trends and patterns.

Some findings:


- People in their 40s were the most likely to die from prescription drugs, followed by those in their 20s and 30s. Teens were the fastest-growing group.

- The dead most often held jobs in manual labor, the service industry or the medical field.

- Most died from overdoses of opioid painkillers, natural or synthetic versions of the opium poppy. The painkillers methadone and oxycodone topped the list.

- A large number also died from overdoses of anti-anxiety drugs such as Xanax and Valium.

- Nearly 70 percent died from an overdose of more than one drug.

The Times' analysis shows the dead are a complex group.
Some are chronic drug abusers who operate on society's fringes.
Others are lawyers, doctors, nurses, school teachers, pastors, college kids, cops, soldiers, business owners and soccer moms.


The autopsy room at the Pinellas-Pasco medical examiner's office is spacious, well-lit and chilly. It smells of disinfectant and bleach. Silver cutting tools sit on a counter. A large walk-in refrigerator stands on one side of the room. Inside are several bodies on steel tables, sheets covering everything but feet. Toes point to the ceiling. About 1,800 bodies are wheeled into this autopsy room every year. Many are scarred with signs of traumatic injury from murders, suicides or car accidents.

Over the past few years, however, more and more bodies have arrived with telltale signs of prescription drug abuse. In most cases, the person accidentally took a toxic amount of a painkiller, which suppressed breathing to the point of death. Medical examiner Dr. Jon Thogmartin says fatal prescription overdoses have soared in the seven years he has been on the job. "We'd probably lose about 25 percent of our work if not for prescription drugs," Thogmartin says.

His counterpart across the bay, Hillsborough County medical examiner Dr. Vernard Adams, says his office had to hire an additional medical examiner to handle the increasing deaths from prescription drugs. To determine the cause and manner of death, Thogmartin and his staff review photos taken at each scene. The photos almost always show the dead person lying in a cluttered home. The beds have no sheets. Dirty dishes are piled in the sink. Liquor bottles and rotted food are scattered on spare furnishings.

At the beginning of each autopsy, Thogmartin also notes scars or tattoos on each body. He often finds scars on the back or neck of those who overdosed on prescription drugs. This leads Thogmartin to believe a legitimate injury from a car crash or workplace may have put them on a path to the morgue.

Thogmartin's observations echo the Times' analysis:

- 54 percent of the dead had a history of pain or injury while 36 percent had a history of emotional pain, usually depression. 69 percent had one or the other.

- 80 percent had a substance abuse problem.

- 52 percent had a history of addiction and pain, whether physical or emotional.

Prescription drugs relieved pain but also ended lives.

Sharon Simpson had asked her fiance, Michael Wood, to hide her pills so she wouldn't take them too fast. He stuffed them in a sock drawer in the bedroom of their Pinellas Park apartment. Sharon found them in the wee hours of New Year's Day. Before daybreak, she was dead. Like many who die of prescription drug overdose, Sharon struggled with substance abuse, chronic pain and emotional turmoil. Her father beat her mother. Sharon turned to drugs and alcohol at an early age. She was pregnant by 14, said her sister, Carrie Nelson.
With multiple men, Sharon birthed four children, none of whom she was raising at the time of her death. She worked for a credit card company.

In recent years, Sharon suffered chronic back pain from a fall and a car accident.
She was taking the painkiller hydrocodone and the muscle relaxant Soma.
Despite her troubles, Sharon was outgoing and funny. She enjoyed the beach and taking walks.

Hours before she died, the couple had celebrated New Year's Eve at a bowling alley. Sharon had several beers and a glass of champagne as she greeted 2006. Back at home, Sharon found the pills before she went to bed. Minutes after they lay down, Michael heard Sharon snoring and gurgling. He shook her. She vomited but would not wake. An ambulance took her to the hospital, where she was pronounced dead.
The medical examiner said she died of an accidental overdose of Soma. Alcohol was a contributing factor. Sharon was 33. Michael says he had feared Sharon might overdose and had talked to her about seeking other ways to treat her pain. Sharon had agreed to do that in the new year.

At the end of the 1990s, cocaine and heroin had a grip on Florida.
Deaths from heroin had doubled since 1995 to more than 200 a year. Cocaine deaths were surging.
But in 2000 medical examiners noticed fatal overdoses from prescription drugs began to outpace deaths from cocaine and heroin. From 2003 to 2006, statewide deaths from prescription drugs grew by 40 percent, while heroin deaths shrank dramatically.

Painkiller prescriptions written by doctors also increased.

From 1997 to 2005, retail sales of five leading painkillers doubled in Florida, according to an Associated Press analysis. In St. Petersburg, retail sales of two of the five painkillers increased more than anywhere else in the state. "The drug companies have replaced the Mexican drug lord," says Larry Golbom, a Pinellas pharmacist who hosts a radio show that focuses on prescription drug addiction.

Several factors contributed to the increase in prescriptions and deaths:


- Drug dealers saw new profits in prescription drugs, which are now commonly sold on the street.
- Inattentive physicians have been duped by doctor shoppers; a few doctors have cashed in on the demand for pills by knowingly prescribing to addicts or dealers.

- Advocacy for chronic pain patients increased, pushing more doctors to prescribe narcotics.

- Insurance sometimes won't pay for pain treatment plans, leaving pills as the only option.

Nationwide, more than 15,000 people died from adverse reactions to drug treatment in 2005, though experts say that number likely is low because reporting is voluntary. Most of those deaths were from pain pills.


Prescription drugs also have killed a number of high-profile celebrities recently, including actor Heath Ledger and model Anna Nicole Smith.

On a rainy July morning in 2007, dozens of people gathered near a courthouse in the tiny Appalachian town of Abingdon, Va. Many carried handmade signs with photos of loved ones. One woman held a tiny urn filled with her son's ashes. Most of them had traveled from Florida, many from Tampa Bay. Each had a personal, tragic story about the painkiller OxyContin. Most of them were parents whose children had fatally overdosed on the drug.

Inside the courthouse, a federal judge scolded executives of Purdue Pharma, the drug company that introduced OxyContin in 1995 as a miracle pain reliever. The federal government had lodged criminal charges against the company because, for years, Purdue Pharma downplayed the addiction potential of OxyContin. Doctors nationwide had prescribed it for minor pain and watched as patients got addicted or fatally overdosed. As part of an agreement with prosecutors, the judge fined the company $600-million and three executives an additional $34.5-million for misbranding the drug. It was one of the largest settlements of its kind in U.S. history.

Perhaps no other prescription drug has drawn more ire than OxyContin, which is why so many people traveled hundreds of miles to Abingdon to rebuke Purdue Pharma in court.
The drug is a semisynthetic opioid with a slow-release mechanism providing patients hours of pain relief. Many pain patients praise its efficacy and say it has saved lives. But drug abusers learned the slow-release mechanism could be removed by crushing the pills, causing a fast, intense high similar to heroin. OxyContin abuse most infamously ripped through the Appalachians, earning it the nickname Hillbilly Heroin.

Abuse of the drug swept through Florida as well. Since 2001, more than 2,000 Floridians have died of overdoses of oxycodone, the active ingredient in OxyContin and other painkillers like Percocet.

But another drug has killed even more.

Bama Richardson was working toward a pharmacy technician degree when he injured his back in a car crash a few years ago. He feared getting hooked on painkillers like OxyContin, which he had heard about in class. A doctor prescribed him methadone. "My son thought it was a miracle drug," said his mother, Mary Richardson, who lives in Alabama. "He said, 'Mama, it doesn't get me high and I can still work.' "

Known primarily for weaning addicts off heroin, methadone is now more widely used to treat addiction to painkillers. Methadone is an effective painkiller itself. As OxyContin's reputation soured over the past decade, more doctors turned to methadone to treat pain. Prescriptions tripled from 1998 to 2003. It's much cheaper than OxyContin and doesn't provide the fast, dramatic high of other opiates. This is why Bama was happy to get it. In March 2006, after not hearing from her son for several days, Mary Richardson went to his Tampa apartment and found him dead, a victim of methadone overdose. He was 21.

His mother was shocked when she researched the drug online. She learned methadone overtook oxycodone as the leading prescription drug killer in Florida in 2002. It has killed 3,000 Floridians over the past five years.

Unlike some painkillers, methadone stays in a person's body long after its initial effects have worn off - sometimes up to five days. A person taking more methadone or other drugs or alcohol may not realize the methadone is stowed in their body. The combination may lead to overdose. Though methadone doesn't provide a fast high, drug abusers may seek it for the euphoria it causes if mixed with alcohol or drugs like Xanax. Abusers also seek methadone to stave off withdrawal when they run out of dope. If they later obtain other drugs and take them, the combination can lead to overdose. But methadone doesn't just kill junkies. It also kills pain patients, who may take an extra pill or two, ignorant of the risks. Mary Richardson suspects this happened to her son.

Though some doctors are scared to prescribe methadone, others are forced to because insurance policies may not pay for more expensive drugs. Methadone costs pennies per pill compared to dollars for other pain pills. "So if you don't have good health insurance, you get methadone," says Thogmartin, the Pinellas-Pasco medical examiner. "Methadone is cheaper, generic, long-lasting. It's sort of the uninsured person's OxyContin."

The mounting deaths worry people like Marc Kleinman, director of clinical services at the Operation PAR methadone clinic in New Port Richey. On a recent morning, Kleinman's clinic was bustling with young women with children, men who looked like your grandfather and middle-aged people who looked like life had worked them over pretty good. They were there for a cup of orange liquid methadone that staves off withdrawal and cravings. Twenty years ago, 70 percent of the clients were here for heroin addiction. Today, 70 percent come because of prescription drug addiction."A lot of our patients never engaged in heroin, they just became addicted to opiates through pain medication," Kleinman says. But the people overdosing on methadone aren't getting it from clinics: A state drug study found only 17 of the 716 deaths caused by methadone in 2006 were people enrolled at methadone clinics.

The problem, Kleinman says, is that more prescriptions from doctors means more drugs wind up in the wrong hands. Those uneducated about methadone tend to mix it with other drugs. Of the 250 people who died of methadone overdoses in the bay area in 2005 and 2006, only about 20 percent overdosed solely on methadone.

Mixing of drugs is not a problem specific to methadone. More than two-thirds of all Tampa Bay area prescription deaths in 2005 and 2006 were caused by a combination of two or more drugs. Abusers mix drugs to enhance their high or to ease the after effects.

As a group of teenagers in Seminole found out on a cool December night, this is risky behavior. Money was tight and Christmas was coming. Robert Sheats and Lauren Burke needed extra cash. Burke, 26, had a brain tumor and was prescribed fentanyl, a painkiller far more potent than morphine. It's designed for people with severe pain and comes in many forms including - of all things - a lollipop. Sheats gave 30 fentanyl lollipops to Michael Bartlett, whom he knew from the neighborhood. Sheats told Bartlett, 18, to sell the pops to his friends and bring back the money, authorities said. Bartlett sold some lollipops at a Seminole house party thrown by 16-year-old C.J. Civitella and his sister Kristi, 17. Their mother, Karen Kennedy, a single mom, was out that night, authorities said. C.J., a lanky boy with short blond hair, had a history of abusing marijuana and Xanax. He and his sister took Xanax that night. C.J. also sucked on at least one lollipop. Around midnight, C.J.'s sister found him passed out in the bathroom. Friends helped him into bed. Somebody drew vulgar pictures and sayings on his chest and neck with a marker, then pulled a blanket over him. The next morning, C.J.'s sister and her friends checked on him and found his eyes open, his skin purple, his body stiff.

The medical examiner's office ruled his death an accidental overdose of Xanax and fentanyl.
Bartlett, Burke and Sheats were arrested on charges of delivering a controlled substance. Burke and Sheats received three years of probation. Bartlett awaits trial.
"We just didn't think right," Burke told a detective in an interview. "We didn't think ... that someone would die."

Kristi and her mother moved in with a woman whose daughter also had died of a prescription drug overdose.Kristi Civitella says she hasn't touched drugs since her brother's death. She recently made a list of young people she knew in the Seminole area who had died of prescription drug overdoses. Including her brother, she counted six. Fourteen teenagers died of accidental prescription drug overdoses in the Tampa Bay area in 2006, up from nine the year before. In the first six months of 2007 alone, the number already had reached 12.
Several studies over the past few years have found that prescription drugs are becoming a favorite among teenagers, prompting some to label today's young people Generation Rx.
More than 70 percent of young people say home medicine cabinets are their source, and more than half believe prescription drugs aren't as dangerous as the street variety, studies show.
Teens gather at "pharm parties" or "skittles parties" where they mix prescription drugs to get high. S
ometimes these kinds of gatherings end badly, as they did for C.J. Civitella.

Prescription drugs also are claiming people in their 20s at an increasing rate, with 57 dying in 2005 and 79 in 2006 in the bay area. The area was on pace to lose more than 100 people in their 20s to accidental prescription drug overdoses in 2007. Drug treatment centers report an increase in young people seeking rehab for prescription drug addictions. Some of them started taking drugs to get high, but many were shown at an early age that pills would solve their problems.

"Mom would wake up every day with her orange juice and a bowl of cereal and three pills," says Christopher Neilson, assistant program manager at Goodwill Industries' drug treatment center in St. Petersburg. "And a lot of those kids ... were on hyperactivity medications when they were young, so it's already been conditioned in them that if you can't behave yourself in school, what do you do? I need a pill."

Matt Dorn wrapped gauze under his chin and around his head, then sucked on his gums until they bled. He spit the blood onto his bandages and hobbled into a pharmacy in Pasco County, where 20 waiting customers allowed him to cut to the front of the line. He received a bounty of powerful painkillers with a forged prescription. "If you could win an Emmy for that, I probably would have won an Emmy," Dorn says. Dorn was a prescription drug abuser who snorted and injected dozens of pills per day. The drugs didn't kill him, but they did ruin his life.
The funny, fast-talking 25-year-old grew up in a happy family in a nice subdivision in Port Richey. His father worked in construction, his mother in the title business.
At age 15, Dorn hurt his ankle in football. Dorn said his parents gave him a Vicodin, which his father had taken for a work injury. The pills made him feel good. "It was love at first sight," Dorn recalls. "You have no fear, no doubts, no negativity." Dorn doesn't blame his parents. He would have tried pills eventually. They were all over his high school. "Crack is real dirty and no one wants to do it and heroin is real dirty and no one wants to do it," Dorn says. "But pills? If your parents are doing it and everybody's doing it, then it's okay." He built a tolerance to the pills and needed more. By 18, he was waking up "dope sick" every morning. To stave off body aches and vomiting, he started his days with 10 Vicodins. Then he made the jump to powerful OxyContins. His tolerance soared. His morning sickness deepened. Dorn needed 10 80-milligram OxyContins just to make it through the day. "You can't do anything until you get that fix," Dorn says. "And that's where you start doing crazy stuff." That included pawning tools from his dad's garage and electronics he stole from stores. The pills led him to crack cocaine, which he sold to buy more pills. "I was chasing (pills) every day. That's all I did for 3 1/2 to four years is chasing," Dorn says. "I couldn't have a good day unless I had a good amount of oxies."

At one point, Dorn bought two sheets from a stolen prescription pad. He made copies, picked names from the phone book and faked Social Security numbers to call in bogus prescriptions. He even took a pharmacy technician class at a community college, where he hoped to learn a few tricks. His run ended when he turned to leave a pharmacy one day and three cops were waiting. He was charged with drug trafficking. Dorn stayed in jail for about six months.
The first few weeks without drugs he endured muscle spasms, vomiting, body aches, cramps, dry heaving, defecating on himself.
Dorn took a deal with prosecutors that got him five years of drug offender probation, including more than a year of residential drug treatment at Operation PAR in Largo. He was released in December 2006 and says he has been clean since. He doesn't miss the scene. "There's professional doctor shoppers, people who have contacts in pharmacies and doctors' offices who sell. People who steal pads. They wash scripts and hang them out to dry like in a photo lab. They make them on a computer.
"It's a whole corrupt little underworld."


Debbie Curry, 52, flips through family photos of her daughter. She can tell which ones were taken when Marissa was abusing prescription drugs. "The eyes always told me," Debbie says. "Look. She's got that zoned-out look. We don't keep a lot of those pictures around." Debbie's insight about prescription drugs isn't limited to her daughter's blue eyes. The Seminole mortgage broker suffers from chronic back pain, so she understands prescription drugs from two sides: they can enrich life by relieving pain, but they also can summon death. Marissa abused prescription drugs after she was injured in a car accident in 2000. That led to heroin abuse, several near-fatal overdoses, an arrest, 18 months in drug treatment and, finally, sobriety. But a second car accident caused more neck and back pain. She went to a doctor, who wrote a prescription for 120 painkillers called Lortab. Debbie thinks Marissa took some of those pills and sold the rest to buy heroin. The next morning, Marissa's boyfriend found her dead in bed at a St. Petersburg hotel. She was 24. Blood tests showed she overdosed on two kinds of painkillers and heroin. Alcohol, marijuana and two anti-anxiety drugs also were in her system.

Despite her daughter's death, Debbie Curry believes prescription narcotics should be available for pain patients who need them. She says doctors must be more vigilant about keeping them from addicts. "It was like giving her a loaded gun," Debbie says. "If you're an addict, you can take one pill and you might as well go back to Square One. There has to be some kind of a system. A happy medium somewhere. I just don't know where it is." Every night, Debbie takes the painkiller Percocet, which dulls her pain and helps her get to bed.

She falls asleep next to Marissa's ashes.



What Your Doctor May Not Know About Methadone

Frank's family called me a year ago after Frank went to a local hospital for a stomach ache. The physicians suspected an ulcer or a bleed and decided to keep him overnight. Frank had a history of back surgery and had been on 100 mg of morphine daily for a year. When Frank was admitted, he asked if he could make a call and get a family member to bring his morphine for his chronic back issue. The physician told Frank "no" and said they would take care of getting him the morphine from the hospital pharmacy. For whatever reason, Frank's gastroenterologist called in a neurologist to consult on getting Frank his morphine. The neurologist told Frank she was going to give Frank methadone instead of morphine-- that it was also an analgesic and would work like morphine. So the neurologist wrote an order for methadone 100 mg to replace Frank's 100 mg morphine. The mistake in the neurologist's conversion of morphine to methadone cost Frank his life. He went into respiratory depression within several hours, coded, was resuscitated and eventually transferred to ICU in a coma on a ventilator.
Phyllis Lile-King

Link To learn more about our methadone legal cases

What is Respiratory Depression?

Methadone toxicity often manifests itself-- causing death by something called respiratory depression or central nervous system depression. Respiration is controlled principally through the part of the brain called the medullary respiratory center with peripheral input from chemoreceptors and other sources. We all understand that breathing is something that is involuntary-- like blinking ones eyes or beating one's heart. We don't "make ourselves breathe." Rather, chemoreceptors in the carotid arteries measure CO2 levels and transmit that information to the brain, which then directs the diaphragm and intercostals/lungs to "breathe." Thank goodness for this process. It would be difficult to sleep if we had to worry about making our bodies breathe. Opioids like methadone inhibit the chemoreceptors via mu opioid receptors and in the medulla via mu and delta receptors. While there are a number of neurotransmitters mediating the control of respiration, glutamate and GABA are the major excitatory and inhibitory neurotransmitters, respectively. So, a simpler way to understand this is to say that methadone interferes with the messages the chemoreceptors send to the brain. Methadone desensitizes the medulla, making the brain unaware of the need for the lungs to breathe. The result is respiratory depression. Families report that the son or daughter feels really sleepy, falls asleep and , the lucky families report that the child is difficult to awaken during the respiratory depression process. The unlucky mother tells me that she heard her son snoring heavily, and found him dead the next morning. Phyllis Lile-King
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Signs of Methadone Overdose

From the methadone hydrochloride package insert:

Deaths, cardiac and respiratory, have been reported during initiation and conversion of pain
patients to methadone treatment from treatment with other opioid agonists. It is critical to
understand the pharmacokinetics of methadone when converting patients from other opioids (see DOSAGE AND ADMINISTRATION). Particular vigilance is necessary during treatment
initiation, during conversion from one opioid to another, and during dose titration.
Respiratory depression is the chief hazard associated with methadone hydrochloride
administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects, particularly in the early dosing period. These characteristics can contribute to cases of iatrogenic overdose, particularly during treatment initiation and dose titration.

In addition, cases of QT interval prolongation and serious arrhythmia (torsades de pointes) have
been observed during treatment with methadone. Most cases involve patients being treated for
pain with large, multiple daily doses of methadone, although cases have been reported in patients receiving doses commonly used for maintenance treatment of opioid addiction.
Methadone treatment for analgesic therapy in patients with acute or chronic pain should only be
initiated if the potential analgesic or palliative care benefit of treatment with methadone is
considered and outweighs the risks.

Link To learn more

William's story

William's wife called a couple of month's back. She found William dead. She had no idea what had happened. He had a history of cardiac blockage and high blood pressure, but was only 60 and seemed fine. When the autopsy came back and the medical examiner said "methadone toxicity" was the cause of death, she was puzzled. She told me William had been on a steady dose of methadone for several months. His pill counts showed that he took the methadone only as directed. How could methadone have killed William? I had no idea. I asked to see the autopsy report and the medical records. William had been prescribed a steady dose of methadone for 9 months. But a month before he died, his doctor began prescribing a class of drugs known as benzodiazepines-- drugs like xanax and valium. Many doctors know that benzodiazepines can increase the effects of methadone, and therefore, are usually not given in conjunction with methadone. Unfortunately, William's doctor did not know this. And William died as a result. Phyllis Lile-King

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Prescription Drug Outranks Cocaine and Heroin as No. 1 Killer

At the time, I was in the middle of a methadone death case. We had filed suit on behalf of a 40-something year old executive with sciatica who was given 360 methadone pills by his pain doctor along with a prescription which read, "Take 1-4, 4 times a day." His eight year old found him dead in bed on the third day.

I had downloaded the epidemiological study from Kay Sanford at the North Carolina Department of Health and Human Services. This was a study of North Carolina unintentional poisoning deaths from 1997-2001. In the study, the numbers confounded me. Before my first methadone case a couple of years earlier, I had hardly heard of the drug methadone. It seems there was scant mention of methadone in law school in connection with some discrimination case I was assigned. The issue was whether an employer could refuse to hire candidates who failed a drug screen based on their attendance at a methadone clinic. Methadone clinics had something to do with heroin detox, I knew. But this seemed an obscure drug and obscure issue, and I did not think about methadone for the next ten years. But during this methadone death case, I read the Sanford study. In that study, Sanford reported that from the time period 1997 to 2000, methadone went from being responsible for 7 deaths in North Carolina to outranking cocaine and heroin as the number 1 killer drug. Methadone deaths increase 729% from 1997 to 2001. Cocaine was top killer drug in 1997, and 1999, while heroin edged out cocaine as the top killer in 1998. But beginning in 2000, methadone-- a prescription drug, has killed more people in this state than any other street drug.

North Carolina is not alone. The National Center for Health Statistics and others have also noticed that deaths from methadone across the country are skyrocketing. What does it mean when a prescription drug kills more people than illegal street drugs like cocaine and heroin? In my mind it means that our controls on prescription methadone are not good. While I do not know how many deaths are from physician prescriptions, how many deaths are occurring at methadone clinics and how many are occurring from buying on the street, also called "diversion," I do not believe that all or even most of the deaths are a result of prescriptions being diverted for street sales. I get calls every week from people who have lost a child, usually a son, as a result of a dose given to him at a methadone clinic, or as a result of an aggressive prescription from a pain physician. In Kay Sanford's study of methadone deaths, of the medical examiner reports that contained information about the source of the methadone, 29% of the deaths occurred to patients prescribed methadone by physicians. Only 19% of the deaths occurred as a result of use of methadone obtained on the street. One person was a patient of a methadone clinic. One was given methadone by a physician during a hospitalization.

I have been told by a pharmacist that our legal work has changed his practices. I have been told by a lawyer that a case I brought led to a physician's office changing its methadone prescribing habits. I have been told that a regulator has taken notice and is looking closely at clinics where patients are dying. This is slow work trying to change the landscape, but if you think this is important, drop me a line and let me know. I have some ideas. Phyllis Lile-King